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Pharmacology 1, POTE

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Description

Flashcards for the subject pharmacology 1 at the medical university of Pécs, Hungary. Made by Sofia and Nikolas

Sample (from 420 notes)

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Front In what ways can a drug alter the effect of an enzyme?
Back Drugs can competitively or non–competitively inhibit enzymes.
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Front Which are the most important phase II enzymes?
Back Transferases, like UGT and NAT.
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Front What is the mechanism of action of methyldopa?
Back Methyldopa is a false substrate for DOPA decarboxylase. The enzyme converts it into methyldopamine which is further converted into methylnoradrenaline.\n\n\nMethylnoradrenaline has little activity on α1 receptors but high activity on α2 receptors, thereby increasing the negative feedback.\n\n\nBecause it is a false substrate for DOPA decarboxylase it will also compete with L–DOPA, so it reduces the amount of noradrenaline formed.
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