Pharmacology 1, POTE
Sample (from 420 notes)
|Front||In what ways can a drug alter the effect of an enzyme?|
|Back||Drugs can competitively or non–competitively inhibit enzymes.|
|Front||Which are the most important phase II enzymes?|
|Back||Transferases, like UGT and NAT.|
|Front||What is the mechanism of action of methyldopa?|
|Back||Methyldopa is a false substrate for DOPA decarboxylase. The enzyme converts it into methyldopamine which is further converted into methylnoradrenaline.\n\n\nMethylnoradrenaline has little activity on α1 receptors but high activity on α2 receptors, thereby increasing the negative feedback.\n\n\nBecause it is a false substrate for DOPA decarboxylase it will also compete with L–DOPA, so it reduces the amount of noradrenaline formed.|
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