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Sketchy micro pepper deck

118.02MB. 0 audio & 1873 images. Updated 2019-10-16.
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Sketchy Micro

Sample (from 105 notes)

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Extra Q Name 3 ways you can distinguish Shigella from Salmonella
Extra A ShigellaSalmonellaGreen on HektoenBlack on HektoenImmotileMotileAcid stableAcid labile
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Extra Q2 Describe how Shigella infects cells
Extra A2 (1) Induces phagocytosis by M-cells(2) Uses actin filaments to escape(Once escaped, it's phagocytosed by MΦs, and then induces apoptosis and subsequent Inflammation.)
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Extra Q3 What type of diarrhea does Shigella cause?
Extra A3 (1) Inflammatory(2) ⇒ Bloody
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Extra Q4 What population gets HUS from Shigella?
Extra A4 Children <10 years old(Due to Shigella DYSENTERIAE. Also associated with Reitter's syndrome.)
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Extra Q5 MOA: Shiga toxin
Extra A5 Inhibits 60s ribosome
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Extra Q6 Name 3 enteric bacteria with Type III secretion systems
Extra A6 (1) Shigella(2) Salmonella(3) Y. enterocolitica
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Entire Sketch 5.3 - Shigella
Tags #SketchyMicro #SketchyMicro::Bacteria::(05)-Gram_(-)_Bacilli-GI::5.03-Shigella $$Bacteria $Gram_(-)_Bacilli-Enteric
Extra Q What is Hansen's disease?
Extra A Leprosy
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Extra Q2 Why does Leprosy predominantly affect the extensor surfaces?
Extra A2 Prefers cold temperatures
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Extra Q3 What comprises the acid-fast stain?
Extra A3 Carbol fuschin
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Extra Q4 Which immune response predominates in the tuberculoid form of leprosy?
Extra A4 Th1
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Extra Q5 Which immune response predominates in the lepromatous form of leprosy?
Extra A5 Th2(⇒ Humoral response ∴ Poorly forms granulomas)
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Extra Q6 What is the main symptom of tuberculoid leprosy?
Extra A6 Well demarcated hair loss(Anywhere, not just head)
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Extra Q7 How do you perform a Lepromin skin test?
Extra A7 Inject leprosy antigen ⇒ Type IV hypersensitivity
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Extra Q8 Which form of leprosy has human to human transmission?
Extra A8 Lepromatous(Notice that they're holding hands, representing transmission)
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Extra Q9 Name 3 signs/symptoms of lepromatous leprosy
Extra A9 (1) Symmetric glove and stocking neuropathy(2) Skin lesions on extensor surfaces(3) "Leonine facies"
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Extra Q10 Treatment: Tuberculoid leprosy
Extra A10 (1) Dapsone(2) Rifampin(For ~9 months)
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Extra Q11 Treatment: Lepromatous leprosy
Extra A11 (1) Dapsone(2) Rifampin(3) Clofazimine(For up to 5 years)
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Entire Sketch 8.2 - Mycobacterium leprae
Tags #SketchyMicro #SketchyMicro::Bacteria::(08)-Mycobacteria::8.2-Mycobacterium_leprae $$Bacteria $Mycobacteria
Extra Q Characterize (2) : Mycobacterium tuberculosis
Extra A (1) Acid fast(2) Obligate aerobe(Facultative intracellular vs. M. leprae which is OBLIGATE intracellular)
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Extra Q2 What component of the mycobacterial cell wall takes up the Carbol-Fuschin stain?
Extra A2 Mycolic acid
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Extra Q3 What culture medium can be used to grow M. tuberculosis?
Extra A3 Lowenstein-Jensen
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Extra Q4 What is the function of Cord factor?
Extra A4 Stimulates MΦs to make granulomas(It activates MΦs, promoting granuloma formation by stimulating TNF-α release)
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Extra Q5 MOA: Sulfatides (in regards to TB)
Extra A5 Inhibits fusion of phagolysosome ⇒ Allows intracellular survival
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Extra Q6 Where does primary TB affect?
Extra A6 Lower/Middle lobes of lung
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Extra Q7 What is a Ghon complex?
Extra A7 After PRIMARY tuberculosis, the following are present:(1) Fibrotic/calcified lung lesions(2) Big hilar lymph nodes(⇒ Fibrosis and calcification = Ranke complex)
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Extra Q8 What is the most common outcome of primary TB?
Extra A8 Lesions heal/fibrose ⇒ Latent(People usually contract primary TB in childhood)
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Extra Q9 Why might someone who has never been exposed to TB have a positive PPD?
Extra A9 BCG vaccine(Common in those from countries where TB is endemic)
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Extra Q10 What do you call it when primary TB results in bacteremia?
Extra A10 Miliary TB(⇒ Seeding of many different organs)
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Extra Q11 What cytokine is required to prevent reactivation of TB?
Extra A11 TNF-α (∴ TNF-α inhibitors ⇒ Reactivation. TNF-α also leads to cachexia, explaining associated weight loss)
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Extra Q12 What part of the lung does secondary TB affect?
Extra A12 Upper lobes
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Extra Q13 Name the triad of symptoms of reactivation TB
Extra A13 (1) Cough(2) Hemoptysis(3) Night sweats
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Extra Q14 What is called when TB infects the vertebrae?
Extra A14 Pott's disease
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Extra Q15 Other than the lung, where can TB produce cavitary lesions?
Extra A15 CNS
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Extra Q16 Treatment: M. tuberculosis
Extra A16 (1) Rifampin(2) Isoniazid(3) Pyriazinamide(4) Ethambutol
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Entire Sketch 8.1 - Mycobacterium tuberculosis
Tags #SketchyMicro #SketchyMicro::Bacteria::(08)-Mycobacteria::8.1-Mycobacterium_tuberculosis $$Bacteria $Mycobacteria

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Well created deck!!!!!