

Pharmacology 2, POTE
0.11MB. 0 audio & 0 images. Updated 2020-12-27.
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Front | Mechanism of action of loop diuretics? |
Back | They are secreted into the filtrate through drug transporters OAT1, OAT4 and MRP4. \n\n\nThey inhibit the Na+/K+/2Cl symporter (NKCC2) in the ascending limb of Henle. This symporter creates the cortico–medullary osmotic gradient. Loop diuretics makes it smaller, and therefore the water reabs decreases in the descending loop and collecting ducts. |
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Front | Which drugs are included in class III and what are their indications? |
Back | Amiodarone and dronedarone. Used in supraventricular and ventricular arrhythmias. |
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Front | How are the pharmacokinetics of amiodarone? |
Back | It's very lipophilic, so it accumulates in tissues and has a half–life of 1 month. |
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